干酪素论文:核壳纳米微球的制备及其对药物的包覆和释放

2014年4月9日

  【中文摘要】本论文采用乳液聚合方法,未使用任何乳化剂和稳定剂,在干酪素(CA)存在下使用叔丁基过氧化氢(TBHP)为引发剂,分别对甲基丙烯酸甲酯(MMA)以及丙烯酸丁酯(BA)进行了在CA上的接枝聚合,制备了直径在150 nm左右的具有核壳结构的PMMA/CA、PBA/CA纳米复合乳胶粒。用透射电镜表征结果证实了乳胶粒的核壳结构,内核分别为憎水的PMMA、PBA,外壳为亲水性的CA。使用激光粒度仪测试了乳胶粒的粒径及其分布,以氯仿为溶剂用索氏提取法测试了PMMA、PBA的接枝效率。探讨了反应温度、引发剂用量、核壳原料质量比、物料总浓度等条件对单体转化率、PMMA和PBA的接枝效率、乳胶粒粒径及其分布的影响。制备PMMA/CA核壳纳米颗粒时,单体转化率和乳胶粒粒径随反应时间的变化实验结果表明:聚合开始20 min时,乳胶粒粒径突然降低然后基本保持不变,30 min内单体转化率达到70%,3 h之内增加到73%。当温度控制在70℃和80℃,TBHP用量控制在CA质量的0.18%到0.36%,MMA/CA质量比为4,物料总浓度不超过10%的条件下MMA转化率和PMMA的接枝效率高于75%。CA-MMA总含量达到30%时...

  【英文摘要】With no any surfactant and in the presence of casein (CA), polymethyl methacrylate (PMMA)/CA and polybutylacrylate (PBA)/CA nano-sized core/shell latex particles based on MMA/CA and BA/CA with about 150 nm in diameter were prepared through emulsion polymerization using tert-butyl hydroperoxide (TBHP) as initiator. The designed core-shell structure was confirmed by transmission electron microscopy (TEM) observation. The TEM images of the nanoparticles clearly showed well-defined core-shell morphology, where ...

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